Introduction to COX inhibitors
نویسندگان
چکیده
منابع مشابه
COX-2 inhibitors.
Cyclooxygenase-2 (COX-2) inhibitors constitute a new group of non-steroidal anti-inflammatory drugs (NSAIDs) which, at recommended doses, block prostaglandin production by cyclooxygenase-2, but not by cyclooxygenase-1. Two COX-2 inhibitors are currently available in Australia--celecoxib, which is taken twice daily, and rofecoxib, which is taken once daily. Both drugs act rapidly in providing pa...
متن کاملGastrointestinal bleeding after the introduction of COX 2 inhibitors: ecological study.
Recent evidence suggests a lower risk of upper gastrointestinal haemorrhage for selective cyclooxygenase-2 (COX 2) inhibitors compared with non-selective non-steroidal anti-inflammatory drugs (NSAIDs) at the patient level, although COX 2 inhibitors are likely not devoid of gastrointestinal toxicity. At the population level, however, the widespread proliferation of COX 2 inhibitors might lead to...
متن کاملAnaphylaxis to selective COX-2 inhibitors: an unexpected culprit
Case Report 1 Male, 40 years-old, non-atopic, who was hospitalized due to anaphylactic shock (nausea, vomiting, dyspnea, hypoxia and hypotension) 30 minutes after etoricoxib intake for low-back pain. He was hospitalized 6 months earlier due to acute respiratory insufficiency with mechanical ventilation of unknown etiology that he later related to etoricoxib intake 60 minutes before. He tolerate...
متن کاملCOX-1 and COX-2 products in the gut: therapeutic impact of COX-2 inhibitors.
Despite the considerable range of newly identified disease modifying approaches to the control of the inflammatory process reported over the past 10–20 years, only a few have yet gained widespread clinical acceptance. In contrast, the very recent advent of the class of anti-inflammatory agents termed COX-2 selective inhibitors is already having a significant impact on current clinical prescribi...
متن کاملCyclooxygenase (COX) Inhibitors and the Newborn Kidney
This review summarizes our current understanding of the role of cyclo-oxygenase inhibitors (COXI) in influencing the structural development as well as the function of the developing kidney. COXI administered either during pregnancy or after birth can influence kidney development including nephronogenesis, and can decrease renal perfusion and ultrafiltration potentially leading to acute kidney i...
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ژورنال
عنوان ژورنال: Future Medicinal Chemistry
سال: 2018
ISSN: 1756-8919,1756-8927
DOI: 10.4155/fmc-2018-0159